Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885655 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL14583766 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3878906 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL13761509 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3877690 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3877853 | 1.00 | TRPV1 (0.46) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3882335 | 0.95 | TRPV1 (0.47) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3880542 | 0.95 | TRPV1 (0.47) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3878509 | 0.95 | TRPV1 (0.47) | TRPV1HSD11B1MAP3K12CHRM4SYK | |
| SCHEMBL3876192 | 0.95 | TRPV1 (0.47) | TRPV1HSD11B1MAP3K12CHRM4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |