Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.47 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878509 | 1.00 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3876192 | 1.00 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3877910 | 1.00 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3880542 | 1.00 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3880804 | 0.97 | TRPV1 (0.47) | TRPV1MALT1CHRM4HSD11B1 | |
| SCHEMBL3877385 | 0.95 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3879150 | 0.95 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 | |
| SCHEMBL3878906 | 0.95 | TRPV1 (0.46) | TRPV1MAP3K12CHRM4HSD11B1SYK | |
| SCHEMBL3877690 | 0.95 | TRPV1 (0.46) | TRPV1MAP3K12CHRM4HSD11B1SYK | |
| SCHEMBL3883287 | 0.95 | TRPV1 (0.47) | TRPV1MAP3K12MALT1CHRM4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027155-A1 | Biaryl piperazinyl-pyridine analogues | GPR174, GPR68, PPARG | TRPV1 244/4885MAP3K12 2603/4885MALT1 1393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.