Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344748 | 0.86 | GNRHR (0.47) | TSHRGSK3BALDH1A1STAT3GNRHR | |
| SCHEMBL3868260 | 0.85 | GSK3B (0.42) | TSHRGSK3BALDH1A1TDP1STAT3 | |
| SCHEMBL1343459 | 0.81 | CHRM1 (0.56) | GSK3B | |
| SCHEMBL1344953 | 0.75 | STAT3 (0.49) | TSHRGSK3BALDH1A1TDP1STAT3 | |
| SCHEMBL1344861 | 0.72 | GNRHR (0.45) | TSHRALDH1A1STAT3GNRHR | |
| SCHEMBL5868740 | 0.71 | FOXO1 (0.53) | TSHRMAPK1GSK3BALDH1A1STAT3 | |
| SCHEMBL1344855 | 0.70 | GSK3B (0.52) | TSHRMAPK1GSK3BSTAT3 | |
| SCHEMBL15999500 | 0.69 | TSHR (0.52) | TSHRMAPK1ALDH1A1TDP1STAT3 | |
| SCHEMBL3870889 | 0.69 | FOXO1 (0.40) | MAPK1GSK3BALDH1A1TDP1STAT3 | |
| SCHEMBL14845071 | 0.69 | TSHR (0.47) | TSHRMAPK1ALDH1A1TDP1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013182-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | Activx Biosciences, Inc. (US) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007106537-A2 | AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2007-09-20 | — | — | WO | disclosed |