⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethyne SCHEMBL10357623 | 0.82 | — | — | |
| SCHEMBL687192 | 0.78 | — | — | |
| SCHEMBL15619251 | 0.78 | — | — | |
| SCHEMBL22251585 | 0.75 | ALDH1A1 (0.38) | — | |
| SCHEMBL9344184 | 0.72 | — | — | |
| SCHEMBL9521720 | 0.71 | — | — | |
| Isopropyl Alcohol SCHEMBL20590526 | 0.70 | ALDH1A1 (0.40) | — | |
| Acetic Acid SCHEMBL11212519 | 0.68 | FFAR3 (0.44) | — | |
| Propanol SCHEMBL20590519 | 0.66 | ALDH1A1 (0.33) | — | |
| SCHEMBL2889732 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827444-B1 | MNK1 OR MNK2 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2013-05-15 | — | — | EP | disclosed |
| US-20090163520-A1 | MNK1 or MNK2 Inhibitors | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2009-06-25 | — | — | US | disclosed |
| US-20080280941-A1 | 8-Phenoxy-Gamma Carboline Derivatives | PHARMA C S.A. (FR) | 2008-11-13 | — | — | US | disclosed |
| EP-1827444-A2 | MNK1 OR MNK2 INHIBITORS | DeveloGen Aktiengesellschaft (DE) | 2007-09-05 | — | — | EP | disclosed |
| EP-1756102-A1 | 8-PHENOXY-GammaCARBOLINE DERIVATIVES | Pharma C S.A. (FR) | 2007-02-28 | — | — | EP | disclosed |
| WO-2007009485-A1 | SUBSTITUTED 8-PHENOXY-Y-CARBOLINE DERIVATIVES WITH 5HT1 ACTIVITY | PHARMA C S.A. (FR) | 2007-01-25 | — | — | WO | disclosed |
| EP-1746099-A1 | Mnk1 or Mnk2 inhibitors | DeveloGen Aktiengesellschaft (DE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2006066937-A2 | MNK1 OR MNK2 INHIBITORS | DEVELOGEN AKTIENGESELLSCHAFT (DE) | 2006-06-29 | — | — | WO | disclosed |
| WO-2005095396-A1 | 8-PHENOXY-Ϝ CARBOLINE DERIVATIVES | PHARMA C S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |