Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387853 | 1.00 | HRH4 (0.43) | HRH4ACACBPDE10AGRIN2DGRIN3B | |
| SCHEMBL15382207 | 0.84 | HRH4 (0.44) | HRH4PDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL26918962 | 0.79 | ACACB (0.43) | ACACBPDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL26918920 | 0.79 | ACACB (0.43) | ACACBPDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29749147 | 0.78 | RET (0.53) | ACACBPDE10AAKR1C3OPRK1 | |
| SCHEMBL13547453 | 0.78 | PDE10A (0.50) | ACACBPDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL30283050 | 0.78 | PDE10A (0.50) | ACACBPDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29782973 | 0.76 | ACACB (0.44) | ACACBAKR1C3PANK3OPRK1OPRM1 | |
| SCHEMBL391497 | 0.73 | PDE10A (0.42) | ACACBPDE10AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10168654 | 0.73 | PDE10A (0.42) | ACACBPDE10AGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101764-B2 | MCH receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-01-24 | — | — | US | disclosed |
| US-20100016350-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016350-A1 | NOVEL MCH RECEPTOR ANTAGONISTS | MCHR1, MCHR2, MC1R | HRH4 105/4885ACACB 4430/4885PDE10A 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.