Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.53 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709581 | 0.90 | RET (0.55) | RETEIF2AK4CKS1BSKP1SKP2 | |
| SCHEMBL31370459 | 0.86 | PDE10A (0.50) | RETEIF2AK4ACACBCPB2PDE10A | |
| SCHEMBL31638498 | 0.85 | RET (0.43) | RETEIF2AK4ACACBOPRK1 | |
| SCHEMBL5738130 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL29921126 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL5516092 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL31286029 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL22795648 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL22795726 | 0.85 | ACACB (0.45) | RETACACBCPB2PDE10ACKS1B | |
| SCHEMBL29782973 | 0.85 | ACACB (0.44) | RETACACBCPB2OPRK1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114907338-A | Nitrogen-containing polycyclic fused ring compound, and pharmaceutical composition, preparation method and application thereof | 北京志健金瑞生物医药科技有限公司 | 2022-08-16 | — | — | CN | disclosed |