Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.59 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.41 |
| ▸ | AOC1 | P19801 | 6/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 6/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12072719 | 0.83 | — | — | |
| SCHEMBL27140192 | 0.81 | LOXL2 (0.73) | LOXL2KCNH3AOC1AOC3HTR6 | |
| Hydrochloric Acid SCHEMBL14486190 | 0.81 | LOXL2 (0.61) | LOXL2KCNH3AOC1AOC3NAMPT | |
| SCHEMBL30824586 | 0.81 | LOXL2 (0.73) | LOXL2KCNH3AOC1AOC3HTR6 | |
| SCHEMBL10284177 | 0.79 | LOXL2 (0.59) | LOXL2KCNH3AOC1AOC3NAMPT | |
| SCHEMBL2090251 | 0.79 | LOXL2 (0.59) | LOXL2KCNH3AOC1AOC3NAMPT | |
| SCHEMBL459017 | 0.79 | LOXL2 (0.59) | LOXL2KCNH3AOC1AOC3NAMPT | |
| SCHEMBL21633180 | 0.76 | LOXL2 (0.55) | LOXL2KCNH3AOC1AOC3NAMPT | |
| SCHEMBL844011 | 0.74 | — | — | |
| SCHEMBL29466769 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069364-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | AstraZeneca AB (SE) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008039138-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3 ] THIAZOLO [4, 5-D] PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | WO | disclosed |