Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880431 | 0.91 | SRC (0.34) | SRC | |
| SCHEMBL3879965 | 0.78 | SRC (0.31) | SRC | |
| SCHEMBL3887939 | 0.78 | SRC (0.33) | SRC | |
| SCHEMBL3880103 | 0.78 | SRC (0.34) | SRCEGFRERBB2 | |
| SCHEMBL3880068 | 0.77 | SRC (0.34) | SRCEGFR | |
| SCHEMBL3880415 | 0.76 | XDH (0.33) | SRCEGFR | |
| SCHEMBL3881251 | 0.76 | SRC (0.32) | SRC | |
| SCHEMBL3881544 | 0.76 | SRC (0.33) | SRC | |
| SCHEMBL3879940 | 0.76 | EGFR (0.34) | SRCEGFRERBB2 | |
| SCHEMBL3890405 | 0.75 | SRC (0.34) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-B1 | QUINOLINE THIAZOLINONES WITH CDK-1 ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | disclosed |