Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 6/20 | 0.57 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880054 | 0.89 | GRM5 (0.45) | UBE2MDCUN1D1LMNAGRM5ALDH1A1 | |
| SCHEMBL3879365 | 0.89 | UBE2M (0.53) | UBE2MDCUN1D1LMNAALDH1A1HPGD | |
| SCHEMBL3882385 | 0.88 | UBE2M (0.43) | UBE2MDCUN1D1LMNAGRM5ALDH1A1 | |
| SCHEMBL3879018 | 0.88 | UBE2M (0.42) | UBE2MDCUN1D1LMNAALDH1A1GAA | |
| SCHEMBL3880259 | 0.85 | NPSR1 (0.48) | UBE2MDCUN1D1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3879091 | 0.85 | UBE2M (0.41) | UBE2MDCUN1D1LMNAALDH1A1GAA | |
| SCHEMBL3877923 | 0.85 | GRM5 (0.44) | UBE2MDCUN1D1LMNAGRM5ALDH1A1 | |
| SCHEMBL3881016 | 0.85 | CYP2C9 (0.42) | UBE2MDCUN1D1LMNAALDH1A1GAA | |
| SCHEMBL3879404 | 0.84 | UBE2M (0.39) | UBE2MDCUN1D1LMNAGRM5ALDH1A1 | |
| SCHEMBL3880379 | 0.84 | UBE2M (0.41) | UBE2MDCUN1D1LMNAGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | claimed |
| EP-1858900-B1 | FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LTD (GB) | 2009-01-07 | — | — | EP | disclosed |