Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.48 |
| ▸ | MTOR | P42345 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882297 | 0.89 | NPSR1 (0.54) | TRPV1MTORHSD11B1GLA | |
| SCHEMBL3879702 | 0.88 | HSD11B1 (0.52) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL3875957 | 0.88 | TRPV1 (0.60) | TRPV1MTORHSD11B1 | |
| SCHEMBL3877210 | 0.88 | HSD11B1 (0.53) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL3889718 | 0.87 | HSD11B1 (0.53) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL14614245 | 0.87 | PIK3CA (0.56) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL3880612 | 0.86 | HSD11B1 (0.55) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL3881365 | 0.84 | HSD11B1 (0.55) | SCN9ATRPV1MTORPIK3CAHSD11B1 | |
| SCHEMBL3877775 | 0.83 | MTOR (0.50) | TRPV1MTORPIK3CAHSD11B1PIK3R1 | |
| SCHEMBL3883874 | 0.83 | HSD11B1 (0.56) | TRPV1MTORPIK3CAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | claimed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |