Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 17/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882673 | 0.92 | DHODH (0.81) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL729482 | 0.82 | DHODH (0.78) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL290518 | 0.82 | DHODH (0.81) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL729186 | 0.82 | DHODH (1.00) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL3873430 | 0.76 | DHODH (0.82) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL1487273 | 0.76 | DHODH (0.76) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL3732485 | 0.76 | DHODH (0.67) | DHODH | |
| SCHEMBL3884284 | 0.75 | DHODH (0.77) | DHODHMEN1KMT2APKMMAPK1 | |
| SCHEMBL3728325 | 0.75 | DHODH (0.67) | DHODH | |
| SCHEMBL3872775 | 0.75 | DHODH (0.69) | DHODHMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121614-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | Almirall, S.A. (ES) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008077639-A1 | AMINO NICOTINIC AND ISONICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-07-03 | — | — | WO | disclosed |