SCHEMBL3882845

SCHEMBL3882845

O=C(Cl)C(=O)Cl.[Ar]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27575648 0.94 TSHR (0.39)
SCHEMBL30250687 0.94
SCHEMBL17225094 0.94
SCHEMBL112 0.94
SCHEMBL17710801 0.88
SCHEMBL233610 0.88
Phosphine SCHEMBL11897664 0.88
Hydrochloric Acid SCHEMBL649123 0.88
SCHEMBL11198303 0.88 TSHR (0.36)
SCHEMBL28837695 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731607-A1 PIPERIDINE, PYRROLIDINE AND ISOINDOLE PRECURSORS OF PROBES FOR OXIDATIVE STRESS Centre National de la Recherche Scientifique (FR) 2026-04-29 EP disclosed
WO-2024261041-A1 PIPERIDINE, PYRROLIDINE AND ISOINDOLE PRECURSORS OF PROBES FOR OXIDATIVE STRESS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2024-12-26 WO disclosed
US-20240059658-A1 QUINOLINE DERIVATIVES AND USES IN MANAGING CANCER UNIV EMORY (US) 2024-02-22 US disclosed
US-20220289720-A1 ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS UNIVERSITY OF HAWAII 2022-09-15 US disclosed
WO-2021016333-A1 ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS UNIVERSITY OF HAWAII (US) 2021-01-28 WO disclosed
EP-2751104-B1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS NOVARTIS AG (CH) 2019-09-25 EP disclosed
EP-2673278-B1 N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS BACE1 AND/OR BACE2 INHIBITORS HOFFMANN LA ROCHE (CH) 2016-12-14 EP disclosed
US-9023839-B2 Compounds and compositions as c-kit kinase inhibitors IRM LLC (BM) 2015-05-05 US disclosed
US-20140228347-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS IRM LLC (BM) 2014-08-14 US disclosed
EP-2751104-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS IRM LLC (BM) 2014-07-09 EP disclosed
EP-2673278-A1 N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS BACE1 AND/OR BACE2 INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2013-12-18 EP disclosed
US-8569283-B2 Compounds and compositions as c-Kit kinase inhibitors IRM LLC (BM) 2013-10-29 US disclosed
US-8404680-B2 N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors HOFFMANN-LA ROCHE INC. (US) 2013-03-26 US disclosed
US-20130059832-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS IRM LLC (BM) 2013-03-07 US disclosed
WO-2013033167-A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS IRM LLC (BM) 2013-03-07 WO disclosed
WO-2012107371-A1 N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-08-16 WO disclosed
US-20120202803-A1 N-[3-(5-AMINO-3,3A,7,7A-TETRAHYDRO-1H-2,4-DIOXA-6-AZA-INDEN-7-YL)-PHENYL]-AMIDES AS BACE1 AND/OR BACE2 INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2012-08-09 US disclosed
EP-1856052-B1 NK1 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2009-09-02 EP disclosed
EP-1856052-A2 NK1 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2007-11-21 EP disclosed
WO-2006089658-A2 NK1 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2006-08-31 WO disclosed