Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2999544 | 0.81 | HSD11B1 (0.48) | HSD11B1CNR1 | |
| SCHEMBL2986879 | 0.80 | CNR1 (0.39) | HSD11B1CNR1PDPK1CNR2 | |
| SCHEMBL2995796 | 0.70 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL4508107 | 0.69 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL3546132 | 0.69 | HSD11B1 (0.51) | HSD11B1CNR1CNR2 | |
| SCHEMBL2997600 | 0.69 | PDPK1 (0.44) | HSD11B1CNR1PDPK1CNR2 | |
| SCHEMBL2997277 | 0.68 | HSD11B1 (0.55) | HSD11B1 | |
| SCHEMBL209343 | 0.67 | HSD11B1 (0.54) | HSD11B1CNR1 | |
| SCHEMBL2992038 | 0.67 | HSD11B1 (0.54) | HSD11B1 | |
| SCHEMBL3000826 | 0.67 | HSD11B1 (0.56) | HSD11B1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-B1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | LILLY CO ELI (US) | 2009-01-07 | — | — | EP | claimed |
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |