Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880527 | 1.00 | FUCA1 (0.54) | FUCA1GBA1MAPTALDH1A1S1PR5 | |
| SCHEMBL1237636 | 0.90 | FUCA1 (0.45) | FUCA1GBA1S1PR5S1PR1CYP1A2 | |
| SCHEMBL6765544 | 0.90 | FUCA1 (0.45) | FUCA1GBA1S1PR5S1PR1CYP1A2 | |
| SCHEMBL1237635 | 0.90 | FUCA1 (0.45) | FUCA1GBA1S1PR5S1PR1CYP1A2 | |
| SCHEMBL3885157 | 0.84 | DPP4 (0.41) | FUCA1S1PR5S1PR1CYP1A2ALOX15 | |
| SCHEMBL4297271 | 0.81 | HTR4 (0.41) | FUCA1S1PR5S1PR1 | |
| SCHEMBL4297275 | 0.81 | HTR4 (0.41) | FUCA1S1PR5S1PR1 | |
| SCHEMBL15521125 | 0.80 | OGA (0.45) | FUCA1GBA1ALDH1A1S1PR5S1PR1 | |
| SCHEMBL16765361 | 0.80 | FUCA1 (0.44) | FUCA1GBA1MAPTALDH1A1S1PR5 | |
| SCHEMBL19465332 | 0.80 | FUCA1 (0.44) | FUCA1GBA1MAPTALDH1A1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010488-A2 | RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007117559-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |