Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015531 | 1.00 | REN (0.35) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1015530 | 1.00 | REN (0.35) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1014019 | 0.96 | REN (0.35) | RENTMEM97SIGMAR1 | |
| SCHEMBL1014018 | 0.96 | REN (0.35) | RENTMEM97SIGMAR1 | |
| SCHEMBL1017601 | 0.95 | REN (0.33) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1017603 | 0.95 | REN (0.33) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1014767 | 0.94 | REN (0.34) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1014766 | 0.94 | REN (0.34) | RENTMEM97SIGMAR1PDE4B | |
| SCHEMBL1015224 | 0.93 | REN (0.32) | RENPDE4B | |
| SCHEMBL1015225 | 0.93 | REN (0.32) | RENPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934207-B1 | SUBSTITUTED 4-PHENYL PIPERIDINES FOR USE AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2009-03-11 | — | — | EP | disclosed |