Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895899 | 0.99 | GSK3B (0.54) | THRBKMT2AGSK3BKDM4EMAPT | |
| Bromide SCHEMBL6218010 | 0.85 | KMT2A (0.65) | THRBKMT2AGSK3BKDM4EMAPT | |
| Bromide SCHEMBL3891677 | 0.82 | THRB (0.61) | THRBKMT2AKDM4EMAPTGLA | |
| Bromide SCHEMBL1645919 | 0.80 | KMT2A (0.73) | THRBKMT2AKDM4EGLAPOLB | |
| Bromide SCHEMBL3883473 | 0.80 | THRB (0.58) | THRBKMT2AKDM4EMAPTGLA | |
| Bromide SCHEMBL3896616 | 0.80 | THRB (0.58) | THRBKMT2AKDM4EMAPTGLA | |
| SCHEMBL13394254 | 0.79 | KMT2A (0.70) | THRBKMT2AKDM4EGLAPOLB | |
| SCHEMBL4894700 | 0.79 | THRB (0.56) | THRBKMT2AKDM4EMAPTGLA | |
| SCHEMBL4890283 | 0.79 | THRB (0.56) | THRBKMT2AKDM4EMAPTGLA | |
| Bromide SCHEMBL3884058 | 0.75 | KMT2A (0.74) | THRBKMT2AKDM4EMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888063-B1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-01-14 | — | — | EP | disclosed |