Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 13/20 | 0.73 |
| ▸ | RPS6KA1 | Q15418 | 8/20 | 0.73 |
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | GRK2 | P25098 | 4/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3861882 | 0.90 | ROCK1 (0.71) | ROCK1RPS6KA1RPS6KB1GRK2LRRK2 | |
| SCHEMBL3889402 | 0.89 | ROCK1 (0.60) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 | |
| SCHEMBL3885385 | 0.88 | ROCK1 (0.57) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 | |
| SCHEMBL3893789 | 0.86 | ROCK1 (0.73) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 | |
| SCHEMBL3883513 | 0.84 | ROCK1 (1.00) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 | |
| SCHEMBL3889234 | 0.83 | ROCK1 (0.53) | ROCK1RPS6KA1RPS6KB1ROCK2LRRK2 | |
| SCHEMBL3860919 | 0.80 | ROCK1 (0.54) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 | |
| SCHEMBL2569551 | 0.78 | GRK2 (0.81) | ROCK1RPS6KA1RPS6KB1GRK2GRK5 | |
| SCHEMBL3884931 | 0.77 | ROCK1 (0.60) | ROCK1RPS6KA1RPS6KB1ROCK2JAK3 | |
| SCHEMBL3867552 | 0.76 | ROCK1 (0.70) | ROCK1RPS6KA1RPS6KB1ROCK2GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592357-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | claimed |
| EP-1718638-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-22 | — | — | EP | claimed |
| US-20080058384-A1 | Novel Compounds | GLAXOSMITHKLINE LLC | 2008-03-06 | — | — | US | claimed |
| EP-1718638-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-08 | — | — | EP | claimed |
| WO-2005082890-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-09 | — | — | WO | claimed |
| US-7592357-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592357-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| US-7592357-B2 | Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-09-22 | — | — | US | disclosed |
| EP-1718638-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-04-22 | — | — | EP | disclosed |
| US-20080058384-A1 | Novel Compounds | GLAXOSMITHKLINE LLC | 2008-03-06 | — | — | US | disclosed |
| US-20080058384-A1 | Novel Compounds | GLAXOSMITHKLINE LLC | 2008-03-06 | — | — | US | disclosed |
| US-20080058384-A1 | Novel Compounds | GLAXOSMITHKLINE LLC | 2008-03-06 | — | — | US | disclosed |
| EP-1718638-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082890-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058384-A1 | Novel Compounds | ARHGDIB, TNK2, ROCK2 | ROCK1 6/4885RPS6KA1 304/4885RPS6KB1 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.