Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13761506 | 1.00 | TRPV1 (0.38) | TRPV1SMOMALT1KCNH2DGAT1 | |
| SCHEMBL3879468 | 0.93 | TRPV1 (0.38) | TRPV1SMOMALT1 | |
| SCHEMBL13761549 | 0.93 | MALT1 (0.40) | TRPV1SMOMALT1 | |
| SCHEMBL3885538 | 0.93 | MALT1 (0.40) | TRPV1SMOMALT1 | |
| SCHEMBL3884028 | 0.93 | MALT1 (0.40) | TRPV1SMOMALT1 | |
| SCHEMBL3889401 | 0.92 | TRPV1 (0.40) | TRPV1SMOMALT1DGAT1 | |
| SCHEMBL3876436 | 0.92 | SMO (0.41) | TRPV1SMODGAT1 | |
| SCHEMBL3876440 | 0.92 | SMO (0.41) | TRPV1SMODGAT1 | |
| SCHEMBL3877069 | 0.89 | TRPV1 (0.44) | TRPV1 | |
| SCHEMBL3876588 | 0.89 | TRPV1 (0.36) | TRPV1MALT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |