Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8651327 | 0.86 | TSHR (0.43) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL215848 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL27387712 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL29405565 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL10779050 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL11864172 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL11818909 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10706430 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL1376362 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL27476174 | 0.84 | TSHR (0.45) | TSHRSMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477998-B1 | ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS INCLUDING SAID COMPOUNDS, AND HYDROCYANATION METHOD USING SAID CATALYTIC SYSTEMS | RHODIA OPERATIONS (FR) | 2014-02-26 | — | — | EP | disclosed |
| US-8546589-B2 | Organophosphorus compounds, catalytic systems comprising said compounds and method of hydrocyanation using said catalytic systems | RHODIA OPERATIONS (FR) | 2013-10-01 | — | — | US | disclosed |
| US-20130053580-A1 | ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS COMPRISING SAID COMPOUNDS AND METHOD OF HYDROCYANATION USING SAID CATALYTIC SYSTEMS | RHODIA OPERATIONS (FR) | 2013-02-28 | — | — | US | disclosed |
| EP-2477998-A1 | ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS INCLUDING SAID COMPOUNDS, AND HYDROCYANATION METHOD USING SAID CATALYTIC SYSTEMS | Rhodia Opérations (FR) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011032835-A1 | ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS INCLUDING SAID COMPOUNDS, AND HYDROCYANATION METHOD USING SAID CATALYTIC SYSTEMS | RHODIA OPERATIONS (FR) | 2011-03-24 | — | — | WO | disclosed |
| US-7521575-B2 | Sterically hindered chelate phosphinite-phosphite ligand, catalyst, comprising at least one nickel(0) complex stabilized by said ligand and method for production of nitriles | BASF AKTIENGESELLSCHAFT (DE) | 2009-04-21 | — | — | US | disclosed |
| US-20070060766-A1 | Sterically hindered chelate phosphinite-phosphite ligand, catalyst, comprising at least one nickel(0) complex stabilized by said ligand and method for production of nitriles | BASF AKTIENGESELLSCHAFT (DE) | 2007-03-15 | — | — | US | disclosed |
| EP-1133356-B1 | HYDROFORMYLATION PROCESS USING CHLOROPHOSPHITE-METAL CATALYST SYSTEM | EASTMAN CHEM CO (US) | 2004-03-17 | — | — | EP | disclosed |
| EP-1133356-A1 | HYDROFORMYLATION PROCESS USING CHLOROPHOSPHITE-METAL CATALYST SYSTEM | EASTMAN CHEMICAL COMPANY (US) | 2001-09-19 | — | — | EP | disclosed |
| US-6232263-B1 | ONE OR MORE TRANSITION METALS SELECTED FROM THE GROUP VIII METALS AND RHENIUM AND ONE OR MORE CHLOROPHOSPHITE | EASTMAN CHEMICAL COMPANY | 2001-05-15 | — | — | US | disclosed |
| US-6130358-A | Hydroformylation process using novel phosphite-metal catalyst system | EASTMAN CHEMICAL COMPANY (US) | 2000-10-10 | — | — | US | disclosed |
| WO-2000023187-A1 | HYDROFORMYLATION PROCESS USING CHLOROPHOSPHITE-METAL CATALYST SYSTEM | EASTMAN CHEMICAL COMPANY (US) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060766-A1 | Sterically hindered chelate phosphinite-phosphite ligand, catalyst, comprising at least one nickel(0) complex stabilized by said ligand and method for production of nitriles | H1-3, H1-2, H1-4 | TSHR 1017/4885SMN1; SMN2 1699/4885NPC1 1141/4885 |
| US-20130053580-A1 | ORGANOPHOSPHORUS COMPOUNDS, CATALYTIC SYSTEMS COMPRISING SAID COMPOUNDS AND METHOD OF HYDROCYANATION USING SAID CATALYTIC SYSTEMS | ACHE, DDT, PNPO | TSHR 3160/4885SMN1; SMN2 2607/4885NPC1 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.