Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892614 | 0.83 | S1PR1 (0.46) | S1PR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL3887088 | 0.81 | S1PR1 (0.44) | S1PR1TSHRNPSR1MEN1KMT2A | |
| SCHEMBL3889414 | 0.74 | S1PR1 (0.77) | S1PR1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL3893550 | 0.73 | MAPT (0.53) | TSHRNPSR1MEN1KMT2ATBXA2R | |
| SCHEMBL3885557 | 0.70 | MAPT (0.55) | TSHRNPSR1MEN1KMT2ATBXA2R | |
| SCHEMBL11883523 | 0.70 | CA1 (0.68) | TSHRNPSR1MEN1KMT2ATBXA2R | |
| SCHEMBL9754552 | 0.68 | MEN1 (0.84) | TSHRNPSR1MEN1KMT2ATBXA2R | |
| SCHEMBL13296438 | 0.67 | TSHR (0.63) | TSHRNPSR1MEN1KMT2AALDH1A1 | |
| SCHEMBL66631 | 0.67 | TSHR (0.62) | TSHRNPSR1MEN1KMT2ATBXA2R | |
| SCHEMBL7920724 | 0.67 | TSHR (0.67) | TSHRNPSR1MEN1KMT2ATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013184-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129019-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |