SCHEMBL7920724

SCHEMBL7920724

O=S(=O)(NCCS)c1ccc(Cl)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
ALDH1A1 P00352 4/20 0.57
KMT2A Q03164 4/20 0.57
MEN1 O00255 3/20 0.57
TP53 P04637 1/20 0.57
GAA P10253 1/20 0.57
KDM4E B2RXH2 1/20 0.57
CA1 P00915 3/20 0.53
CA2 P00918 3/20 0.53
CYP19A1 P11511 1/20 0.53
TBXA2R P21731 1/20 0.53
MAPT P10636 1/20 0.53
CA12 O43570 1/20 0.52
CA3 P07451 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9512956 0.89 TSHR (0.63) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL66632 0.85 CYP3A4 (0.70) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL20851314 0.84 ALDH1A1 (0.59) TSHRNPSR1ALDH1A1KMT2AMEN1
Hydrochloric Acid SCHEMBL1580080 0.83 CYP3A4 (0.68) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL9577200 0.82 ALDH1A1 (0.68) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL7023027 0.82 TSHR (0.64) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL11883523 0.81 CA1 (0.68) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL5352151 0.81 TSHR (0.62) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL66631 0.81 TSHR (0.62) TSHRNPSR1ALDH1A1KMT2AMEN1
SCHEMBL19392401 0.81 ALDH1A1 (0.50) TSHRNPSR1ALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0811375-B1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA LTD (JP) 2001-01-03 EP disclosed
US-5955505-A TREATING NERVE DEGENERATIVE DISORDERS NIPPON SUISAN KAISHA, LTD. (JP) 1999-09-21 US disclosed
EP-0811375-A1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA, LTD. (JP) 1997-12-10 EP disclosed
EP-0469901-B1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO LTD (JP) 1994-10-19 EP disclosed
US-5189211-A Thromboxane A2 antagonists TAISHO PHARMACEUTICAL CO., LTD. (JP) 1993-02-23 US disclosed
EP-0469901-A1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1992-02-05 EP disclosed