Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.82 |
| ▸ | ITGAV | P06756 | 20/20 | 0.82 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889422 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL7944308 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL4378963 | 1.00 | ITGB3 (0.82) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL3893571 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL3885035 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL3886509 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL3885043 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB6 | |
| SCHEMBL4381844 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB6 | |
| SCHEMBL7936743 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB6 | |
| SCHEMBL4381840 | 0.86 | ITGAV (0.61) | ITGB3ITGAVITGA2BITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | claimed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | claimed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | claimed |
| EP-1047425-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-04-22 | — | — | EP | disclosed |
| US-6268378-B1 | TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |
| EP-1047425-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-11-02 | — | — | EP | disclosed |
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | disclosed |
| WO-1999030709-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1999-06-24 | — | — | WO | disclosed |