Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 16/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889786 | 1.00 | OPRL1 (0.50) | OPRL1OPRM1OPRK1MAOBMAOA | |
| Hydrochloric Acid SCHEMBL3902607 | 0.99 | OPRL1 (0.49) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL3902601 | 0.99 | OPRL1 (0.49) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3895271 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1OPRK1MAOB | |
| SCHEMBL3895269 | 0.88 | OPRL1 (0.51) | OPRL1OPRM1OPRK1MAOB | |
| Hydrochloric Acid SCHEMBL3890275 | 0.86 | OPRL1 (0.50) | OPRL1OPRM1OPRK1MAOB | |
| Hydrochloric Acid SCHEMBL3890271 | 0.86 | OPRL1 (0.50) | OPRL1OPRM1OPRK1MAOB | |
| SCHEMBL4850302 | 0.73 | OPRL1 (0.54) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4850308 | 0.73 | OPRL1 (0.54) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3144057 | 0.73 | OPRL1 (0.62) | OPRL1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560806-B1 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-10 | — | — | EP | claimed |
| EP-1560806-A2 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | claimed |
| WO-2004043900-A2 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | claimed |
| US-7507758-B2 | 4-alkyl-/4-alkenyl-/4-alkynyl methyl/-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2009-03-24 | — | — | US | disclosed |
| EP-1560806-B1 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-01-10 | — | — | EP | disclosed |
| US-20050267107-A1 | 4-alkyl-/4-alkenyl-/4-alkynyl methyl/-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
| EP-1560806-A2 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004043900-A2 | 4-ALKYL/4-ALKENYL/4-ALKYNYL METHYL/-1-ARYLCYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267107-A1 | 4-alkyl-/4-alkenyl-/4-alkynyl methyl/-1-aryl-cyclohexylamine compounds | OPRL1, OPRM1, OGFRL1 | OPRL1 1/4885OPRM1 2/4885OPRK1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.