Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 20/20 | 0.53 |
| ▸ | EDNRB | P24530 | 18/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4240721 | 0.80 | EDNRA (0.79) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4907853 | 0.80 | EDNRA (0.59) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7219972 | 0.77 | EDNRA (0.53) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4907860 | 0.69 | EDNRA (0.75) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6150890 | 0.69 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL29372653 | 0.69 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL803344 | 0.69 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| Sitaxentan SCHEMBL4142779 | 0.69 | EDNRA (0.98) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL15139978 | 0.69 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL8555870 | 0.68 | EDNRA (0.64) | EDNRAEDNRBABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127426-A1 | POLYMER-FREE STENTS COMPRISING AN ENDOTHELIN RECEPTOR ANTAGONIST | VON KORN HUBERTUS (DE) | 2009-10-22 | — | — | WO | disclosed |
| EP-2110148-A1 | Polymer-free stents comprising an endothelin receptor antagonist | von Korn, Hubertus (DE) | 2009-10-21 | — | — | EP | disclosed |