Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.53 |
| ▸ | EDNRB | P24530 | 17/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048101 | 0.88 | EDNRA (0.68) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4907853 | 0.82 | EDNRA (0.59) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL4240721 | 0.79 | EDNRA (0.79) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL3890891 | 0.77 | EDNRA (0.53) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7046595 | 0.71 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL4907860 | 0.69 | EDNRA (0.75) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL6150890 | 0.69 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4ABCB11 | |
| SCHEMBL7048930 | 0.69 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL7047483 | 0.69 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL7047487 | 0.68 | EDNRA (0.48) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632829-B2 | Thienyl, furyl and pyrrolyl-sulfonamides, useful for treating hypertension, cardiovascular disease, asthma, pulmonary hypertension, inflammatory diseases, vision defects, menstrual disorders, renal failure and other diseases | TEXAS BIOTECHNOLOGY CORP. | 2003-10-14 | — | — | US | claimed |
| EP-1342721-A1 | Sulfonamides and derivatives thereof that modulate the activity of endothelin | ENCYSIVE PHARMACEUTICALS INC. (US) | 2003-09-10 | — | — | EP | claimed |