Anirolac

Anirolac

SCHEMBL38909

COc1ccc(C(=O)c2ccc3n2CCC3C(=O)O)cc1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.71
CDC42 P60953 3/20 0.71
RAC1 P63000 3/20 0.71
PTGS1 P23219 2/20 0.71
PAK1 Q13153 2/20 0.71
NPC1 O15118 1/20 0.71
CHRM3 P20309 1/20 0.71
OPRM1 P35372 1/20 0.71
RAB9A P51151 1/20 0.71
ABCC4 O15439 1/20 0.62
HTT P42858 1/20 0.62
BLM P54132 1/20 0.62
LMNA P02545 1/20 0.62
CYP1A2 P05177 1/20 0.62
NFKB1 P19838 1/20 0.62
MAPK1 P28482 1/20 0.62
GAA P10253 2/20 0.47
CA4 P22748 5/20 0.46
CA9 Q16790 4/20 0.46
CA1 P00915 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Anirolac SCHEMBL17378021 1.00 PTGS2 (0.71) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11194579 0.93 PTGS2 (0.61) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11195795 0.91 PTGS2 (0.60) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL24205758 0.90 PTGS2 (0.57) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL17384893 0.89 PTGS2 (0.55) PTGS2CDC42RAC1PTGS1PAK1
Anirolac SCHEMBL11602217 0.88 PTGS2 (0.54) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11606365 0.86 PTGS2 (0.67) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11345344 0.86 PTGS2 (0.67) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11158093 0.86 PTGS2 (0.53) PTGS2CDC42RAC1PTGS1PAK1
SCHEMBL11064891 0.85 PTGS2 (0.69) PTGS2CDC42RAC1PTGS1PAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3684 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4335413-A2 PROSTHETIC TISSUE VALVES Cormatrix Cardiovascular, Inc. (US) 2024-03-13 EP claimed
US-20220110979-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC 2022-04-14 US claimed
EP-3908297-A1 FIBROBLAST REGENERATIVE CELLS Figene, LLC (US) 2021-11-17 EP claimed
US-11136342-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2021-10-05 US claimed
EP-3279663-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2021-07-28 EP claimed
WO-2020146874-A1 FIBROBLAST REGENERATIVE CELLS FIGENE, LLC (US) 2020-07-16 WO claimed
US-20200157126-A1 CARBONATE PRODRUGS AND METHODS OF USING THE SAME ACORDA THERAPEUTICS, INC. 2020-05-21 US claimed
EP-3279663-A1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES The Brigham and Women's Hospital, Inc. (US) 2018-02-07 EP claimed
US-20170281724-A9 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2017-10-05 US claimed
EP-2001496-B1 USE OF GELSOLIN TO DIAGNOSE AND TREAT INFLAMMATORY DISEASES BRIGHAM & WOMENS HOSPITAL INC (US) 2017-05-31 EP claimed
WO-1998043630-A1 MEANS OF ASCERTAINING AN INDIVIDUAL'S RISK PROFILE FOR ATHEROSCLEROTIC DISEASE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 1998-10-08 WO claimed
US-5360611-A Antiinflammatory ALCON LABORATORIES, INC. (US) 1994-11-01 US claimed
EP-0284076-B1 Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds SYNTEX INC (US) 1994-06-08 EP claimed
EP-0275092-B1 PROCESS FOR PREPARING (+)-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1,7-DICARBOXYLATES SYNTEX (U.S.A.) INC. (US) 1992-06-03 EP claimed
EP-0289262-A2 Omega-quaternary ammonium alkyl esters and thioesters of acidic nonsteroidal antiinflammatory drugs SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1988-11-02 EP claimed
EP-0284076-A1 Process for preparing (+)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds SYNTEX (U.S.A.) INC. (US) 1988-09-28 EP claimed
EP-0275092-A1 Process for preparing (+)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1,7-dicarboxylates SYNTEX (U.S.A.) INC. (US) 1988-07-20 EP claimed
US-4457941-A RETINOPATHY, NEUROPATHY, NEPHROPATHY SYNTEX (U.S.A.) INC. (US) 1984-07-03 US claimed
US-4454151-A Use of pyrrolo pyrroles in treatment of ophthalmic diseases SYNTEX (U.S.A.) INC. (US) 1984-06-12 US claimed
US-4089969-A ANTIINFLAMMATORY, ANALGESIC, ANTIPYRETIC, SMOOTH MUSCLE RELAXANT SYNTEX (U.S.A.) INC. (US) 1978-05-16 US claimed