Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3896811 | 0.95 | HTT (0.42) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL3887038 | 0.91 | CXCL8 (0.47) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL3884629 | 0.80 | CDC7 (0.41) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL14392325 | 0.77 | CXCL8 (0.46) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL3895292 | 0.76 | HTT (0.43) | KDM4EMAPTHTTNPC1RAB9A | |
| SCHEMBL31613387 | 0.74 | KDM4E (0.45) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL26985120 | 0.74 | KDM4E (0.45) | CXCL8KDM4EMAPTHTTNPC1 | |
| SCHEMBL20187445 | 0.74 | ATM (0.43) | KDM4EHTTRAB9AMAPK1ALDH1A1 | |
| SCHEMBL3732479 | 0.73 | KDM4E (0.50) | KDM4EMAPTHTTRAB9AALDH1A1 | |
| SCHEMBL31394030 | 0.72 | ATM (0.50) | KDM4EHTTRAB9AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076486-B2 | Heteroaryl-substituted arylaminopyridine derivatives as MEK inhibitors | MERCK SERONO S.A. (CH) | 2011-12-13 | — | — | US | disclosed |
| EP-2013180-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | Laboratoires Serono SA (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007123936-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | LABORATOIRES SERONO SA (CH) | 2007-11-01 | — | — | WO | disclosed |