Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.54 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.54 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.54 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.54 |
| ▸ | PTPRC | P08575 | 2/20 | 0.54 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.44 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28353710 | 0.80 | POLM (0.48) | POLMPOLKPOLLPOLHKDM4E | |
| SCHEMBL28084879 | 0.79 | POLM (0.50) | POLMPOLKPOLLPOLHKMT2A | |
| SCHEMBL30529677 | 0.78 | POLM (0.54) | POLMPOLKPOLLPOLHPTPRC | |
| SCHEMBL26781784 | 0.78 | POLM (0.54) | POLMPOLKPOLLPOLHPTPRC | |
| SCHEMBL4294847 | 0.78 | PTPRC (0.71) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL5595620 | 0.77 | PTPRC (0.69) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL5595746 | 0.77 | PTPRC (0.69) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL14315096 | 0.76 | POLM (0.66) | POLMPOLKPOLLPOLHKDM4E | |
| SCHEMBL14439324 | 0.76 | PTPN1 (0.62) | PTPRCCDC25BPTPN1ALDH1A1KDM4E | |
| SCHEMBL10407328 | 0.75 | KDM4E (0.68) | POLMPOLKPOLLPOLHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420777-A4 | PHARMACEUTICAL COMPOSITIONS CONTAINING BETA-LAPACHONE, OR DERIVATIVES OR ANALOGS THEREOF, AND METHODS OF USING SAME | ARQULE INC (US) | 2009-03-04 | — | — | EP | disclosed |
| US-7074824-B2 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same | ARQULE, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-20050245599-A1 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same | ARQULE, INC. | 2005-11-03 | — | — | US | disclosed |
| EP-1420777-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING BETA-LAPACHONE, OR DERIVATIVES OR ANALOGS THEREOF, AND METHODS OF USING SAME | ARQULE, INC. (US) | 2004-05-26 | — | — | EP | disclosed |
| US-20040071775-A1 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same | ARQULE, INC. | 2004-04-15 | — | — | US | disclosed |
| WO-2003011224-A2 | PHARMACEUTICAL COMPOSITIONS CONTAINING BETA-LAPACHONE, OR DERIVATIVES OR ANALOGS THEREOF, AND METHODS OF USING SAME | ARQULE, INC. (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245599-A1 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same | LIPA, SQLE, LPXN | POLM 2807/4885POLK 1570/4885POLL 2610/4885 |
| US-20040071775-A1 | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same | LIPA, LSS, SQLE | POLM 2861/4885POLK 1869/4885POLL 2857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.