Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 2/20 | 0.71 |
| ▸ | CDC25B | P30305 | 1/20 | 0.71 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.69 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 3/20 | 0.50 |
| ▸ | CES1 | P23141 | 3/20 | 0.50 |
| ▸ | SOAT1 | P35610 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595620 | 0.98 | PTPRC (0.69) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL5595746 | 0.98 | PTPRC (0.69) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| Naphthoquinone SCHEMBL8525306 | 0.93 | PTPRC (0.61) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL9444193 | 0.87 | CDC25B (0.57) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL9713908 | 0.86 | CDC25B (0.56) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL11247136 | 0.86 | CDC25B (0.56) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL7718306 | 0.86 | PTPRC (0.51) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL7718305 | 0.86 | PTPRC (0.51) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL9628579 | 0.86 | CDC25B (0.56) | PTPRCCDC25BPTPN1APAF1ALDH1A1 | |
| SCHEMBL13611359 | 0.84 | PTPN1 (0.69) | PTPRCCDC25BPTPN1ALDH1A1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888326-B1 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RES FOUND (US) | 2006-08-16 | — | — | EP | claimed |
| JP-2000506841-A | — | — | 2000-06-06 | — | — | JP | claimed |
| US-5977187-A | 4-substituted-1,2-naphthoquinones and their use in the inhibition of neoplastic cell growth | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-11-02 | — | — | US | claimed |
| EP-0888326-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-07 | — | — | EP | claimed |
| EP-0886524-A2 | DELIVERY OF THERAPEUTIC AGENTS TO THE PROSTATE | CHIRON CORPORATION (US) | 1998-12-30 | — | — | EP | claimed |
| WO-1997031611-A2 | TREATMENT OF BEGNIN PROSTATIC HYPERPLASIA | CHIRON CORPORATION (US) | 1997-09-04 | — | — | WO | claimed |
| WO-1997031936-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1997-09-04 | — | — | WO | claimed |
| US-20090275664-A1 | NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES | PROGEN PHARMACEUTICALS, INC. | 2009-11-05 | — | — | US | disclosed |
| US-20080194697-A1 | NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES | CELLGATE, INC. | 2008-08-14 | — | — | US | disclosed |
| US-7279502-B2 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases | CELLGATE, INC. (US) | 2007-10-09 | — | — | US | disclosed |
| US-7253207-B2 | Quinones as disease therapies | CELLGATE, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253207-B2 | Quinones as disease therapies | CELLGATE, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253207-B2 | Quinones as disease therapies | CELLGATE, INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-5969163-A | CONTACTING SOLUTION OF LAWSONE IN DIMETHYL SULFOXIDE AT LOW TEMPERATURE WITH LITHIUM HYDRIDE AND WARMING TO FORM LITHIUM SALT, ALKYLATING WITH ALLYL HALIDE IN PRESENCE OF LITHIUM IODIDE, CYCLIZING ALKYLATED LAWSONE DERIVATIVES | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-10-19 | — | — | US | disclosed |
| US-5883270-A | 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0888326-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0886524-A2 | DELIVERY OF THERAPEUTIC AGENTS TO THE PROSTATE | CHIRON CORPORATION (US) | 1998-12-30 | — | — | EP | disclosed |
| US-5824700-A | ANTICARCINOGENIC AGENTS FOR TREATING BREAST CANCER OR COLON CANCER | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1998-10-20 | — | — | US | disclosed |
| WO-1997031611-A2 | TREATMENT OF BEGNIN PROSTATIC HYPERPLASIA | CHIRON CORPORATION (US) | 1997-09-04 | — | — | WO | disclosed |
| WO-1997031936-A2 | NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1997-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194697-A1 | NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES | CTSB, KLK3, FOLH1 | PTPRC 1472/4885CDC25B 190/4885PTPN1 3701/4885 |
| US-20090275664-A1 | NOVEL POLYAMINE ANALOG CONJUGATES AND QUINONE CONJUGATES AS THERAPIES FOR CANCERS AND PROSTATE DISEASES | CTSB, CTSL, CTSV | PTPRC 1675/4885CDC25B 511/4885PTPN1 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.