Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389692 | 1.00 | NAMPT (0.36) | NAMPTGRIN2BCHRM2CHRM4CHRM5 | |
| SCHEMBL392072 | 0.92 | NAMPT (0.42) | NAMPTGPR119FAAH | |
| SCHEMBL387107 | 0.89 | KCNH2 (0.43) | GRIN2BCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL388621 | 0.87 | GPR119 (0.40) | GRIN2BCHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL392226 | 0.86 | GPR119 (0.39) | NAMPTGRIN2BCHRM2CHRM4CHRM5 | |
| SCHEMBL389896 | 0.85 | GPR119 (0.46) | NAMPTGPR119 | |
| SCHEMBL392229 | 0.84 | GPR119 (0.37) | NAMPTGRIN2BCHRM2CHRM4CHRM5 | |
| SCHEMBL392337 | 0.84 | KCNH2 (0.38) | NAMPTGRIN2BCHRM2CHRM4CHRM5 | |
| SCHEMBL390543 | 0.84 | NAMPT (0.40) | NAMPTGPR119ENPP2 | |
| SCHEMBL3672386 | 0.84 | CHRM2 (0.39) | NAMPTCHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101626-B2 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | ARENA PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |