Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | DAO | P14920 | 1/20 | 0.74 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.74 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.70 |
| ▸ | CES2 | O00748 | 3/20 | 0.70 |
| ▸ | CES1 | P23141 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Methylbenzoic Acid SCHEMBL7940172 | 0.97 | ALDH1A1 (0.85) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| 4-Methylbenzoic Acid SCHEMBL14723409 | 0.97 | ALDH1A1 (0.85) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL5706549 | 0.95 | TSHR (0.74) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL10436416 | 0.95 | TSHR (0.74) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL27993303 | 0.92 | TSHR (0.70) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL28256202 | 0.92 | TSHR (0.70) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| 4-Methylbenzoic Acid SCHEMBL27936299 | 0.92 | ALDH1A1 (0.94) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL29040586 | 0.91 | SMN1; SMN2 (0.67) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL7216440 | 0.90 | TSHR (0.67) | ALDH1A1SMN1; SMN2TSHRDAONAPRT | |
| Benzoic Acid SCHEMBL27639083 | 0.90 | TSHR (0.67) | ALDH1A1SMN1; SMN2TSHRDAONAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117836344-A | Dual cure resin composition comprising uretdione containing compounds and use thereof in 3D printing | 巴斯夫欧洲公司 | 2024-04-05 | — | — | CN | claimed |
| CN-117836344-A | Dual cure resin composition comprising uretdione containing compounds and use thereof in 3D printing | 巴斯夫欧洲公司 | 2024-04-05 | — | — | CN | disclosed |
| US-8518898-B2 | Cytoprotective composition comprising hesperidin or pharmaceutically acceptable salt thereof as an active ingredient | KOREA ATOMIC ENERGY RESEARCH INSTITUTE (KR) | 2013-08-27 | — | — | US | disclosed |
| WO-2009151173-A1 | PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF VIRAL DISEASES CONTAINING RHODIOLA EXTRACTS, FRACTIONS, THE ISOLATED FLAVONOID COMPOUNDS THEREFROM, DERIVATIVES COMPOUNDS THEREOF OR THE PHARMACEUTICALLY ACCEPTABLE SALTS AS AN ACTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-12-17 | — | — | WO | disclosed |
| US-20090227526-A1 | CYTOPROTECTIVE COMPOSITION COMPRISING HESPERIDIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT | KOREA ATOMIC ENERGY RESEARCH INSTITUTE (KR) | 2009-09-10 | — | — | US | disclosed |
| WO-2009102083-A1 | NOVEL CLITOCYBIN DERIVATIVES, PREPARATION METHOD THEREOF AND COMPOSITION CONTAINING THE EXTRACT OF CLITOCYBE AURANTIACA KCTC 11143BP OR THE NOVEL CLITOCYBIN DERIVATIVES FOR PREVENTION OF AGING AS AN ACTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2009-08-20 | — | — | WO | disclosed |
| EP-0962580-B1 | SCREEN-LIKE PLATED ARTICLE COMPRISING MESH-LIKE FABRIC USING SHEATH-CORE COMPOSITE FILAMENTS AND CYLINDER FOR ROTARY SCREEN | KB SEIREN LTD (JP) | 2006-07-19 | — | — | EP | disclosed |
| US-6244173-B1 | Screen-formed plated article comprising mesh cloth using core-sheath composite filament, and cylinder for rotary screen | KANEBO LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0675668-B1 | A damper for a loudspeaker and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO LTD (JP) | 2000-05-31 | — | — | EP | disclosed |
| EP-0962580-A1 | SCREEN-LIKE PLATED ARTICLE COMPRISING MESH-LIKE FABRIC USING SHEATH-CORE COMPOSITE FILAMENTS AND CYLINDER FOR ROTARY SCREEN | Kanebo Limited (JP) | 1999-12-08 | — | — | EP | disclosed |
| US-5966797-A | Method of manufacturing a damper for a loudspeaker | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| US-5878150-A | Damper for a loudspeaker and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1999-03-02 | — | — | US | disclosed |
| EP-0675668-A1 | A damper for a loudspeaker and a method for producing the same | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1995-10-04 | — | — | EP | disclosed |
| EP-0439960-A2 | Mesh fabric for screen printing, process for preparing the same, gauze spanning method thereof and photosensitive film for screen printing plate by use thereof | MURAKAMI SCREEN CO. LTD. (JP) | 1991-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227526-A1 | CYTOPROTECTIVE COMPOSITION COMPRISING HESPERIDIN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS AN ACTIVE INGREDIENT | HES1, PHLPP1, PHLPP2 | ALDH1A1 1033/4885SMN1; SMN2 756/4885TSHR 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.