⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750140 | 0.92 | — | — | |
| SCHEMBL27710723 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL10717466 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL8187524 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL3897705 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL8187522 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL10717470 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL3897707 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL9315797 | 0.89 | TSHR (0.42) | — | |
| SCHEMBL386401 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501846-B1 | TRICYCLIC MACROLIDE ANTIBACTERIAL COMPOUNDS | ABBOTT LAB (US) | 2009-03-18 | — | — | EP | disclosed |
| US-6998390-B2 | Oxolide antibacterials | ABBVIE INC. | 2006-02-14 | — | — | US | disclosed |
| US-6992069-B2 | Tricyclic macrolide antibacterial compounds | ABBVIE INC. | 2006-01-31 | — | — | US | disclosed |
| US-20050267054-A1 | Antibacterial compounds with improved pharmacokinetic profiles | CLARK RICHARD F | 2005-12-01 | — | — | US | disclosed |
| EP-1579864-A1 | Oxolide antibacterials | ABBOTT LABORATORIES (US) | 2005-09-28 | — | — | EP | disclosed |
| US-6933283-B2 | 11-deoxy azalide antibacterials | ABBOTT LABORATORIES (US) | 2005-08-23 | — | — | US | disclosed |
| US-20050130251-A1 | Reagent for determination of hydrogen peroxide | KYOWA MEDEX CO., LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1424554-A1 | REAGENT FOR DETERMINING HYDROGEN PEROXIDE | KYOWA MEDEX CO., LTD. (JP) | 2004-06-02 | — | — | EP | disclosed |
| US-20040033970-A1 | Antibacterial compounds with improved pharmacokinetic profiles | ABBOTT LABORATORIES | 2004-02-19 | — | — | US | disclosed |
| US-20040029818-A1 | Tricyclic macrolide antibacterial compounds | ABBVIE INC. | 2004-02-12 | — | — | US | disclosed |
| US-20040014687-A1 | Macrolide antibacterial compounds | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | disclosed |
| US-20040014688-A1 | Oxolide antibacterials | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
| US-20040014691-A1 | 9-Oxime macrolide antibacterials | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | disclosed |
| US-20040014953-A1 | 11-Deoxy azalide antibacterials | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
| US-20040009932-A1 | Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae | ABBOTT LABORATORIES | 2004-01-15 | — | — | US | disclosed |
| US-20030207820-A1 | Antibacterial compounds with improved pharmacokinetic profiles | ABBOTT LABORATORIES | 2003-11-06 | — | — | US | disclosed |