Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.66 |
| ▸ | METAP2 | P50579 | 2/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | COMT | P21964 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | METAP1 | P53582 | 1/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL28295336 | 0.90 | TSHR (0.81) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL3211964 | 0.90 | TSHR (0.81) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL8931554 | 0.83 | TSHR (0.95) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL5414182 | 0.83 | TSHR (0.95) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL5936977 | 0.83 | TSHR (0.95) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL28162650 | 0.81 | TSHR (0.84) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL27529898 | 0.81 | TSHR (0.91) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL21465316 | 0.81 | TSHR (0.91) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL28138151 | 0.81 | TSHR (0.91) | TSHRMMP2METAP2CHRM1COMT | |
| Oxyquinoline SCHEMBL3357862 | 0.81 | TSHR (0.91) | TSHRMMP2METAP2CHRM1COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773866-A4 | USE OF METAL COMPLEXES | BIO LAYER PTY LTD (AU) | 2009-04-01 | — | — | EP | disclosed |
| EP-1773866-A1 | USE OF METAL COMPLEXES | Bio-Layer Pty Limited (AU) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002472-A1 | USE OF METAL COMPLEXES | BIO-LAYER PTY LTD (AU) | 2006-01-12 | — | — | WO | disclosed |