Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.81 |
| ▸ | MMP2 | P08253 | 2/20 | 0.81 |
| ▸ | METAP2 | P50579 | 2/20 | 0.81 |
| ▸ | COMT | P21964 | 2/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.81 |
| ▸ | METAP1 | P53582 | 1/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.68 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL28295336 | 1.00 | TSHR (0.81) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL28162650 | 0.90 | TSHR (0.84) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL3899683 | 0.90 | TSHR (0.66) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL27529898 | 0.90 | TSHR (0.91) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL29365411 | 0.90 | TSHR (1.00) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL37189 | 0.90 | TSHR (1.00) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL29716519 | 0.90 | TSHR (1.00) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL253313 | 0.90 | TSHR (1.00) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL10869516 | 0.88 | TSHR (0.88) | TSHRMMP2METAP2COMTCHRM1 | |
| Oxyquinoline SCHEMBL28038881 | 0.88 | TSHR (0.88) | TSHRMMP2METAP2COMTCHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117269159-A | Method for simultaneously and quantitatively detecting ferrous iron and ferric iron | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | 2023-12-22 | — | — | CN | claimed |
| CN-116003423-A | Method for synthesizing spiro compound by photocatalysis | 广西大学 | 2023-04-25 | — | — | CN | claimed |
| CN-115901650-A | Method for detecting total amount of guanidines in body fluid of renal failure patient | 西安乐析医疗科技有限公司 | 2023-04-04 | — | — | CN | claimed |
| CN-109239045-B | A kind of molecular engram ratio fluorescent sensor and preparation and application | 中国科学院烟台海岸带研究所 | 2019-03-26 | — | — | CN | claimed |
| CN-109239045-A | A kind of molecular engram ratio fluorescent sensor and preparation and application | 中国科学院烟台海岸带研究所 | 2019-01-18 | — | — | CN | claimed |
| CN-106589219-A | Preparation method for fluorescent hydrotalcite/acrylic resin composite material | 咸阳师范学院 | 2017-04-26 | — | — | CN | claimed |
| CN-103113879-B | Method for coating silicon dioxide on surface of 8-hydroxyquinoline aluminum | UNIV TAIYUAN TECHNOLOGY | 2015-02-25 | — | — | CN | claimed |
| CN-103113879-A | Method for coating silicon dioxide on surface of 8-hydroxyquinoline aluminum | UNIV TAIYUAN TECHNOLOGY | 2013-05-22 | — | — | CN | claimed |
| CN-120847077-A | Method for detecting content of aluminum ions in high-absorptivity resin | 浙江卫星新材料科技有限公司 | 2025-10-28 | — | — | CN | disclosed |
| CN-117269159-A | Method for simultaneously and quantitatively detecting ferrous iron and ferric iron | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | 2023-12-22 | — | — | CN | disclosed |
| CN-117269159-A | Method for simultaneously and quantitatively detecting ferrous iron and ferric iron | 江苏省疾病预防控制中心(江苏省公共卫生研究院) | 2023-12-22 | — | — | CN | disclosed |
| CN-116003423-A | Method for synthesizing spiro compound by photocatalysis | 广西大学 | 2023-04-25 | — | — | CN | disclosed |
| CN-115901650-A | Method for detecting total amount of guanidines in body fluid of renal failure patient | 西安乐析医疗科技有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-113295744-B | Based on CuV2O6And application thereof in arginine detection | 广东省科学院测试分析研究所(中国广州分析测试中心) | 2022-03-11 | — | — | CN | disclosed |
| US-20140296251-A1 | MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS | Annji Pharmaceutical Co., Ltd. (TW) | 2014-10-02 | — | — | US | disclosed |
| CN-103113879-A | Method for coating silicon dioxide on surface of 8-hydroxyquinoline aluminum | UNIV TAIYUAN TECHNOLOGY | 2013-05-22 | — | — | CN | disclosed |
| US-20100047352-A1 | COMPOSITIONS AND METHODS FOR TREATING EXCESSIVE BLEEDING | HEMO NANOSCIENCE, LLC | 2010-02-25 | — | — | US | disclosed |
| EP-1799192-A2 | COMPOSITIONS AND METHODS FOR TREATING EXCESSIVE BLEEDING | Pronovost, Allan D. (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060034935-A1 | Compositions and methods for treating excessive bleeding | HEMO NANOSCIENCE, LLC | 2006-02-16 | — | — | US | disclosed |
| WO-2006012541-A2 | COMPOSITIONS AND METHODS FOR TREATING EXCESSIVE BLEEDING | EISENSON HENRY (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296251-A1 | MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS | NLN, SNCA, CLN6 | MMP8 4387/4885MMP13 4193/4885TSHR 4432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.