Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | SCN1A | P35498 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11807083 | 0.85 | CYP3A4 (0.59) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL11306031 | 0.84 | DRD3 (0.50) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL9295790 | 0.81 | CHRM3 (0.59) | OPRM1DRD3DRD2LMNACYP2D6 | |
| Hydrochloric Acid SCHEMBL11720708 | 0.80 | CYP3A4 (0.54) | OPRM1DRD3DRD2LMNACYP2D6 | |
| Hydrochloric Acid SCHEMBL11716157 | 0.80 | OPRM1 (0.47) | OPRM1DRD3DRD2LMNACYP2D6 | |
| Hydrochloric Acid SCHEMBL11716160 | 0.80 | OPRM1 (0.47) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL13541547 | 0.79 | KCNH2 (0.74) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL10925815 | 0.79 | CYP3A4 (0.51) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL2984162 | 0.78 | CHRM3 (0.56) | OPRM1DRD3DRD2LMNACYP2D6 | |
| SCHEMBL27963558 | 0.78 | CHRM3 (0.55) | OPRM1DRD3DRD2LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1725238-A4 | M 3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-04-01 | — | — | EP | claimed |
| EP-1725238-A2 | M 3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-11-29 | — | — | EP | claimed |
| WO-2005094251-A2 | M3MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-10-13 | — | — | WO | claimed |
| EP-1725238-A4 | M 3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2009-04-01 | — | — | EP | disclosed |
| EP-1725238-A2 | M 3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005094251-A2 | M3MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-10-13 | — | — | WO | disclosed |