Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.79 |
| ▸ | KLKB1 | P03952 | 18/20 | 0.79 |
| ▸ | F10 | P00742 | 2/20 | 0.69 |
| ▸ | PLG | P00747 | 1/20 | 0.58 |
| ▸ | F12 | P00748 | 1/20 | 0.58 |
| ▸ | KLK1 | P06870 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.58 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.58 |
| ▸ | F7 | P08709 | 1/20 | 0.58 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL390071 | 1.00 | F11 (0.79) | F11KLKB1F10PLGF12 | |
| SCHEMBL392450 | 0.90 | F11 (0.81) | F11KLKB1F10PLGF12 | |
| SCHEMBL392451 | 0.90 | F11 (0.81) | F11KLKB1F10PLGF12 | |
| SCHEMBL394819 | 0.88 | F11 (0.74) | F11KLKB1F10 | |
| SCHEMBL394818 | 0.88 | F11 (0.74) | F11KLKB1F10 | |
| SCHEMBL392751 | 0.85 | F11 (0.81) | F11KLKB1F10PLGF12 | |
| SCHEMBL392750 | 0.85 | F11 (0.81) | F11KLKB1F10PLGF12 | |
| SCHEMBL393831 | 0.85 | F11 (0.92) | F11KLKB1F10PLGF12 | |
| SCHEMBL390271 | 0.83 | F11 (0.71) | F11KLKB1F10 | |
| SCHEMBL390272 | 0.83 | F11 (0.71) | F11KLKB1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101778-B2 | Five-membered heterocycles useful as serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-24 | — | — | US | claimed |