Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.92 |
| ▸ | P4HTM | Q9NXG6 | 12/20 | 0.55 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.55 |
| ▸ | MIF | P14174 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157288 | 0.96 | KDM4E (1.00) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| Hydrochloric Acid SCHEMBL5934153 | 0.94 | KDM4E (0.96) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| SCHEMBL3901156 | 0.94 | KDM4E (0.96) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| SCHEMBL16070636 | 0.79 | ALDH1A1 (0.70) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| Lithium Ion SCHEMBL4253136 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| SCHEMBL787729 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1P4HTMP4HA1MIF | |
| SCHEMBL471438 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL157129 | 0.77 | KDM4E (0.67) | KDM4EALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL29539391 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL27660665 | 0.77 | ALDH1A1 (0.67) | KDM4EALDH1A1P4HTMP4HA1MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |