Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 7/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042142 | 0.84 | NOTUM (0.77) | NOTUMMAP4K4TP53ALDH2HDAC6 | |
| SCHEMBL14466739 | 0.80 | NOTUM (0.55) | NOTUMMAP4K4ALDH2TAAR1 | |
| SCHEMBL3476831 | 0.79 | NOTUM (0.64) | NOTUMMAP4K4TDP2ALDH1A1ALDH2 | |
| SCHEMBL4231200 | 0.79 | NOTUM (0.64) | NOTUMMAP4K4ALDH2HDAC6 | |
| SCHEMBL94548 | 0.79 | NOTUM (0.64) | NOTUMMAP4K4ALDH2HDAC6PARP1 | |
| SCHEMBL22151411 | 0.79 | NOTUM (0.58) | NOTUMMAP4K4CYP3A4ALDH2HDAC6 | |
| SCHEMBL14353060 | 0.79 | NOTUM (0.58) | NOTUMMAP4K4ALDH2TAAR1CHEK1 | |
| SCHEMBL1136802 | 0.78 | NOTUM (1.00) | NOTUMMAP4K4TDP2TDP1ALDH2 | |
| Hydrochloric Acid SCHEMBL14353023 | 0.78 | NOTUM (0.53) | NOTUMALDH2TAAR1 | |
| SCHEMBL24196193 | 0.77 | NOTUM (0.52) | NOTUMMAP4K4TDP1ALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286943-A1 | IL-17A MODULATORS | SANOFI (FR) | 2023-09-14 | — | — | US | disclosed |
| CN-116568676-A | IL-17A modulators | 赛诺菲 | 2023-08-08 | — | — | CN | disclosed |
| CN-116547275-A | IL-17A modulators | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| US-20230227427-A1 | IL-17A MODULATORS | SANOFI (FR) | 2023-07-20 | — | — | US | disclosed |
| EP-4157827-A1 | IL-17A MODULATORS | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |
| EP-4157828-A1 | IL-17A MODULATORS | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2021239745-A1 | IL-17A MODULATORS | SANOFI (FR) | 2021-12-02 | — | — | WO | disclosed |
| US-20160296499-A1 | Spiroindoline Antiparasitic Derivatives | ZOETIS SERVICES LLC | 2016-10-13 | — | — | US | disclosed |
| CN-105829311-A | SPIROINDOLINE ANTIPARASITIC DERIVATIVES | 硕腾服务有限责任公司 | 2016-08-03 | — | — | CN | disclosed |
| EP-2016057-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007123516-A1 | C-FMS KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227427-A1 | IL-17A MODULATORS | IL17A, IL2, IL15 | NOTUM 4359/4885MAP4K4 2759/4885TDP2 4482/4885 |
| US-20160296499-A1 | Spiroindoline Antiparasitic Derivatives | PKD2, PKD1, AVPR2 | NOTUM 3248/4885MAP4K4 2097/4885TDP2 3962/4885 |
| US-20230286943-A1 | IL-17A MODULATORS | IL17A, IL2, IL15 | NOTUM 4359/4885MAP4K4 2759/4885TDP2 4482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.