Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | ALDH2 | P05091 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042142 | 0.84 | NOTUM (0.77) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4102273 | 0.79 | MAPK14 (0.53) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3476831 | 0.79 | NOTUM (0.64) | NOTUMALDH2MAPTMAP4K4 | |
| SCHEMBL3901501 | 0.79 | NOTUM (0.64) | NOTUMALDH2MAP4K4HDAC6 | |
| SCHEMBL94548 | 0.79 | NOTUM (0.64) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL133043 | 0.79 | NOTUM (0.58) | NOTUMALDH2MAP4K4HDAC6 | |
| SCHEMBL1136802 | 0.78 | NOTUM (1.00) | NOTUMALDH2MAPTTNKS2MAP4K4 | |
| SCHEMBL24196193 | 0.77 | NOTUM (0.52) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4096565 | 0.76 | MAPK14 (0.47) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20532002 | 0.75 | NOTUM (0.59) | NOTUMMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224396-A1 | COMPOUNDS INHIBITING TDG ACTIVITY | 上海仕谱生物科技有限公司 | 2020-11-12 | — | — | WO | disclosed |
| US-20140163012-A1 | PYRIDO-/AZEPINO-BENZOFURAN AND PYRIDO-/AZEPINO-BENZOTHIOPHENE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-20140163012-A1 | PYRIDO-/AZEPINO-BENZOFURAN AND PYRIDO-/AZEPINO-BENZOTHIOPHENE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | ALBANY MOLECULAR RESEARCH, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| WO-2009137270-A2 | AZETIDINE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009120655-A1 | INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-10-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163012-A1 | PYRIDO-/AZEPINO-BENZOFURAN AND PYRIDO-/AZEPINO-BENZOTHIOPHENE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF | MCHR1, MCHR2, TAAR1 | NOTUM 2457/4885MAPK13 3876/4885MAPK12 3619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.