SCHEMBL3901508

SCHEMBL3901508

CCC(Br)c1ccc(C(=O)O)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
TP53 P04637 1/20 0.48
TSHR P16473 1/20 0.48
HTT P42858 1/20 0.47
ANPEP P15144 1/20 0.47
MAPT P10636 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
SRD5A2 P31213 2/20 0.43
RXRA P19793 2/20 0.42
RXRB P28702 2/20 0.42
DRD1 P21728 2/20 0.42
LMNA P02545 1/20 0.42
ESR1 P03372 1/20 0.42
CYP1A2 P05177 1/20 0.42
PGR P06401 1/20 0.42
CHRM2 P08172 1/20 0.42
CYP3A4 P08684 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
AR P10275 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28095147 0.83 ALDH1A1 (0.53) ALDH1A1HTTMAPTSMN1; SMN2SRD5A2
SCHEMBL9203574 0.82 TSHR (0.50) ALDH1A1TP53TSHRANPEPSMN1; SMN2
SCHEMBL938192 0.81 ALDH1A1 (0.56) ALDH1A1TP53TSHRHTTANPEP
SCHEMBL19922225 0.81 MAPK1 (0.45) ALDH1A1TP53TSHRANPEPMAPT
SCHEMBL8759187 0.79 MAPT (0.50) ALDH1A1TSHRMAPTCYP3A4CYP2D6
SCHEMBL13951793 0.79 HDAC8 (0.63) ALDH1A1TP53TSHRHTTANPEP
SCHEMBL28261561 0.79 TP53 (0.51) ALDH1A1TP53TSHRMAPTKMT2A
SCHEMBL7995537 0.78 SRD5A2 (0.48) HTTSMN1; SMN2SRD5A2CYP2D6CYP2C9
SCHEMBL14549283 0.78 TSHR (0.56) ALDH1A1TP53TSHRHTTANPEP
SCHEMBL115710 0.78 TSHR (0.56) ALDH1A1TP53TSHRHTTANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1768988-B1 NOVEL PHENYL-BORONIC ACID DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF GALDERMA RES & DEV (FR) 2009-01-28 EP disclosed
EP-1768988-A1 NOVEL PHENYL-BORONIC ACID DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF Galderma Research & Development, S.N.C. (FR) 2007-04-04 EP disclosed
WO-2005061520-A1 NOVEL PHENYL-BORONIC ACID DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 2005-07-07 WO disclosed