Sugi Predict

Sugi Predict / Compounds / SCHEMBL390197

SCHEMBL390197

SCHEMBL390197

CON=C(CCC(=O)O)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 2/20 0.50
▸ CYP2D6 P10635 2/20 0.50
▸ CYP2C9 P11712 2/20 0.50
▸ CYP2C19 P33261 2/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ PPARA Q07869 7/20 0.47
▸ PPARG P37231 6/20 0.46
▸ SLC6A4 P31645 1/20 0.46
▸ GSK3B P49841 1/20 0.44
▸ DRD4 P21917 2/20 0.43
▸ DRD2 P14416 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL390196 1.00 CYP1A2 (0.50) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL6419395 0.95 CYP1A2 (0.47) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL6419398 0.95 CYP1A2 (0.47) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL11248774 0.86 PPARA (0.60) PPARAPPARG
SCHEMBL2438177 0.85 CYP1A2 (0.43) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL2438174 0.85 CYP1A2 (0.43) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL28120573 0.85 PPARG (0.61) CYP1A2CYP2C19MEN1KMT2AALDH1A1
SCHEMBL2433059 0.84 SLC6A4 (0.48) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL20953933 0.84 SLC6A4 (0.48) CYP1A2CYP2D6CYP2C9CYP2C19MEN1
SCHEMBL2433062 0.84 SLC6A4 (0.48) CYP1A2CYP2D6CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12252495-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2025-03-18 — — US disclosed
US-20240109902-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2024-04-04 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-11760760-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2023-09-19 — — US disclosed
US-20220220116-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2022-07-14 — — US disclosed
US-11236095-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2022-02-01 — — US disclosed
US-20200239483-A1 PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2020-07-30 — — US disclosed
US-10654855-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2020-05-19 — — US disclosed
US-20180312516-A1 Protein Kinase B Inhibitors ASTRAZENECA AB (SE) 2018-11-01 — — US disclosed
US-10059714-B2 Protein kinase B inhibitors ASTRAZENECA AB (SE) 2018-08-28 — — US disclosed
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2015-07-02 — — US disclosed
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2015-07-02 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2012-07-26 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
US-8101623-B2 Substituted pyrrolo[2,3-d]pyrimidine as a protein kinase B inhibitor ASTRAZENECA AB (SE) 2012-01-24 — — US disclosed
EP-2201012-A1 PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS AstraZeneca AB (SE) 2010-06-30 — — EP disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 ASTRAZENECA AB (SE) 2009-06-25 — — US disclosed
WO-2009047563-A1 PYRROLO [2, 3 -D] PYRIMIDIN DERIVATIVES AS PROTEIN KINASE B INHIBITORS ASTRAZENECA AB (SE) 2009-04-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12252495-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20220220116-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20180312516-A1 Protein Kinase B Inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-10654855-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20240109902-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-10059714-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20090163524-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 CYP1A2 3895/4885CYP2D6 4066/4885CYP2C9 4553/4885
US-20200239483-A1 PROTEIN KINASE B INHIBITORS PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20120190679-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 CYP1A2 3895/4885CYP2D6 4066/4885CYP2C9 4553/4885
US-11236095-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885
US-20150182531-A1 Novel Protein Kinase B Inhibitors - 060 PRKAR2B, PRKCB, MAP3K20 CYP1A2 3895/4885CYP2D6 4066/4885CYP2C9 4553/4885
US-11760760-B2 Protein kinase B inhibitors PRKAR2B, PRKCB, AKT1 CYP1A2 3544/4885CYP2D6 3865/4885CYP2C9 4111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.