Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2324658 | 0.81 | KDM1A (0.52) | HTR2CHTR2B | |
| SCHEMBL2360390 | 0.81 | KDM1A (0.52) | HTR2AHTR2CHTR2BSLC6A3SLC6A2 | |
| SCHEMBL6250772 | 0.81 | KDM1A (0.47) | HSD17B10 | |
| SCHEMBL11965121 | 0.81 | HTR2A (0.44) | HTR2AHTR2CHTR2BSLC6A3SLC6A2 | |
| SCHEMBL2854689 | 0.81 | KDM1A (0.52) | HTR2CHTR2B | |
| SCHEMBL7797793 | 0.81 | DDB1 (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL2359931 | 0.81 | HTR2A (0.44) | HTR2AHTR2CHTR2BSLC6A3SLC6A2 | |
| SCHEMBL2827719 | 0.81 | KDM1A (0.52) | HTR2CHTR2B | |
| SCHEMBL26631497 | 0.80 | HTR2A (0.44) | HTR2AHTR2CHTR2BSLC6A3SLC6A2 | |
| SCHEMBL27275649 | 0.80 | HTR2A (0.41) | HTR2AHTR2CHTR2BSLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | claimed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | claimed |
| CN-105531268-A | Novel compounds and pharmaceutical compositions thereof for the treatment of cystic fibrosis | GALAPAGOS NV | 2016-04-27 | — | — | CN | disclosed |
| WO-2010094029-A2 | ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-08-19 | — | — | WO | disclosed |
| EP-1756063-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2009-03-25 | — | — | EP | disclosed |
| EP-1756063-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005110992-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20030187267-A1 | Novel 1,2,3,4-tetrahydroisoquinoline, their preparation method and their use as fungicides | AVENTIS PHARMA S.A. (FR) | 2003-10-02 | — | — | US | disclosed |
| EP-1272485-A1 | NOVEL 1,2,3,4-TETRAHYDROSIOQUINOLINE, THEIR PREPARATION METHOD AND THEIR USE AS FUNGICIDES | Aventis Pharma S.A. (FR) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001074808-A1 | NOVEL 1,2,3,4-TETRAHYDROSIOQUINOLINE, THEIR PREPARATION METHOD AND THEIR USE AS FUNGICIDES | AVENTIS PHARMA S.A. (FR) | 2001-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187267-A1 | Novel 1,2,3,4-tetrahydroisoquinoline, their preparation method and their use as fungicides | CYP1A1, CBR3, HAAO | HTR2A 1767/4885HTR2C 556/4885HTR2B 1827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.