Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905695 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL3910577 | 0.87 | PTPN1 (0.43) | ALDH1A1MAPTCYP1A2CYP2C19PTPN1 | |
| SCHEMBL3910572 | 0.87 | PTPN1 (0.43) | ALDH1A1MAPTCYP1A2CYP2C19PTPN1 | |
| SCHEMBL3915582 | 0.85 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP1A2CYP2C19PTPN1 | |
| SCHEMBL3915578 | 0.85 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP1A2CYP2C19PTPN1 | |
| SCHEMBL3906804 | 0.85 | PTPN1 (0.54) | KDM4EALDH1A1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL3906798 | 0.85 | PTPN1 (0.54) | KDM4EALDH1A1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL3908555 | 0.84 | ALDH1A1 (0.53) | KDM4EALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL3908214 | 0.78 | TNFRSF1A (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2PTPN1 | |
| SCHEMBL3908211 | 0.78 | TNFRSF1A (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521473-B2 | Inhibitors of protein tyrosine phosphatase 1B | WYETH (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521473-B2 | Inhibitors of protein tyrosine phosphatase 1B | WYETH (US) | 2009-04-21 | — | — | US | disclosed |
| US-7521473-B2 | Inhibitors of protein tyrosine phosphatase 1B | WYETH (US) | 2009-04-21 | — | — | US | disclosed |
| US-20050203087-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081954-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203087-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRO, PTPRS, PTPRM | KDM4E 561/4885ALDH1A1 2158/4885MAPT 3976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.