Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.45 |
| ▸ | CTSK | P43235 | 4/20 | 0.45 |
| ▸ | CTSL | P07711 | 3/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CXCR3 | P49682 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3915390 | 0.97 | CTSS (0.45) | CTSSCTSKCTSLCTSBCXCR3 | |
| SCHEMBL3910878 | 0.95 | CTSS (0.48) | CTSSCTSKCTSLCTSBCXCR3 | |
| Trifluoroacetic Acid SCHEMBL3323721 | 0.95 | CTSS (0.49) | CTSSCTSKCTSLCTSBSLC2A1 | |
| SCHEMBL8140039 | 0.93 | CTSS (0.48) | CTSSCTSKCTSLCTSBCXCR3 | |
| Trifluoroacetic Acid SCHEMBL3321781 | 0.90 | CTSS (0.47) | CTSSCTSKCTSLCTSBSLC2A1 | |
| Trifluoroacetic Acid SCHEMBL3921339 | 0.90 | CTSS (0.43) | CTSSCTSKCTSLCTSBCXCR3 | |
| SCHEMBL8138703 | 0.90 | CTSS (0.54) | CTSSCTSKCTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL3918126 | 0.90 | CTSS (0.43) | CTSSCTSKCTSLCTSBCXCR3 | |
| Trifluoroacetic Acid SCHEMBL3316013 | 0.89 | CTSS (0.45) | CTSSCTSKCTSLCTSBSLC2A1 | |
| Trifluoroacetic Acid SCHEMBL3322320 | 0.87 | CTSS (0.46) | CTSSCTSKCTSLCTSBTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2028182-A1 | Cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2009-02-25 | — | — | EP | claimed |
| EP-1972630-A1 | Purines as cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2008-09-24 | — | — | EP | claimed |
| EP-2028182-A1 | Cysteine protease inhibitors | GLAXO GROUP LIMITED (GB) | 2009-02-25 | — | — | EP | disclosed |