Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.92 |
| ▸ | TP53 | P04637 | 2/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzidine SCHEMBL16009789 | 1.00 | CYP3A4 (0.92) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL10697986 | 0.96 | CYP3A4 (0.85) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL22129123 | 0.96 | CYP3A4 (0.85) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL720393 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| SCHEMBL2024128 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| SCHEMBL28842081 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL29021 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL5140469 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| SCHEMBL258287 | 0.96 | CYP3A4 (1.00) | CYP3A4ALDH1A1TDP1TP53HSD17B10 | |
| Benzidine SCHEMBL25274606 | 0.92 | CYP3A4 (0.92) | CYP3A4ALDH1A1TDP1TP53HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572828-B2 | contacting a nucleocapsid protein of the virus with a antimonyphenyl cpompound containin at least one carboxy, carboxy ester or amide group for inhibiting retroviral replication | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-08-11 | — | — | US | disclosed |
| EP-1575549-A4 | IDENTIFICATION OF ANTI-HIV COMPOUNDS INHIBITING VIRUS ASSEMBLY AND BINDING OF NUCLEOCAPSID PROTEIN TO NUCLEIC ACID | US GOV HEALTH & HUMAN SERV (US) | 2008-05-07 | — | — | EP | disclosed |
| US-20060263772-A1 | Identification of anti-hiv compounds inhibiting virus assembly and binding of nucleocapsid protein to nucleic acid | THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICE (US) | 2006-11-23 | — | — | US | disclosed |
| EP-1575549-A2 | IDENTIFICATION OF ANTI-HIV COMPOUNDS INHIBITING VIRUS ASSEMBLY AND BINDING OF NUCLEOCAPSID PROTEIN TO NUCLEIC ACID | The Government of the USA as represented by the Secretary of the Dept. of Health ahd Human services (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004032869-A2 | IDENTIFICATION OF ANTI-HIV COMPOUNDS INHIBITING VIRUS ASSEMBLY AND BINDING OF NUCLEOCAPSID PROTEIN TO NUCLEIC ACID | THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2004-04-22 | — | — | WO | disclosed |
| WO-2002062333-A9 | USE OF 9H-XANTHENES IN A METHOD OF INHIBITING VIRAL REPLICATION TARGETING THE NUCLEOCAPSID PROTEIN | US GOV HEALTH & HUMAN SERV (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2002062333-A1 | USE OF 9H-XANTHENES IN A METHOD OF INHIBITING VIRAL REPLICATION TARGETING THE NUCLEOCAPSID PROTEIN | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-08-15 | — | — | WO | disclosed |