Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 12/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 5/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14414410 | 0.87 | BRAF (0.37) | ROS1BRAFTGFBR1 | |
| SCHEMBL3918438 | 0.86 | ROS1 (0.60) | ROS1ALKMETBRAFTGFBR1 | |
| SCHEMBL3909956 | 0.85 | ROS1 (0.41) | ROS1ALKMETBRAF | |
| SCHEMBL3979668 | 0.84 | ROS1 (0.49) | ROS1ALKMETBRAF | |
| SCHEMBL3911878 | 0.84 | ROS1 (0.49) | ROS1ALKMETBRAF | |
| SCHEMBL987733 | 0.81 | ROS1 (0.54) | ROS1ALKMETBRAF | |
| SCHEMBL3911292 | 0.81 | ROS1 (0.51) | ROS1ALKMETBRAF | |
| SCHEMBL3911285 | 0.81 | ROS1 (0.51) | ROS1ALKMETBRAF | |
| SCHEMBL3911904 | 0.79 | ROS1 (0.45) | ROS1ALKMETBRAF | |
| SCHEMBL3918762 | 0.79 | ROS1 (0.44) | ROS1ALKMETBRAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024353-A2 | PYRAZOLE COMPOUNDS | Pfizer Products Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007105058-A2 | PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | disclosed |