Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987167 | 0.87 | MEN1 (0.38) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3919321 | 0.84 | SHMT1 (0.36) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL4408276 | 0.83 | MAPT (0.48) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL3063975 | 0.81 | MEN1 (0.42) | MEN1KMT2AHTTALDH1A1LMNA | |
| SCHEMBL4420456 | 0.80 | NPC1 (0.54) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5605441 | 0.80 | PDE4D (0.46) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL2254883 | 0.79 | KDM4E (0.41) | MAPTMEN1KMT2AHTTGAA | |
| SCHEMBL14467319 | 0.77 | HDAC3 (0.44) | GAAALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL5604731 | 0.77 | MAOB (0.56) | MEN1KMT2A | |
| SCHEMBL5604633 | 0.77 | SMPD1 (0.53) | MAPTALDH1A1SMN1; SMN2POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024353-A2 | PYRAZOLE COMPOUNDS | Pfizer Products Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007105058-A2 | PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007105058-A2 | PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-09-20 | — | — | WO | disclosed |