SHMT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL8651252	0.55	17/20
SCHEMBL9001784	0.90	15/20
SCHEMBL9001788	1.00	14/20
SCHEMBL9001800	1.00	14/20
SCHEMBL9001824	0.91	14/20
SCHEMBL9001756	0.78	14/20
SCHEMBL9001780	0.77	14/20
SCHEMBL9001783	0.75	14/20
SCHEMBL9001790	0.73	14/20
SCHEMBL9001818	0.73	14/20
SCHEMBL9001755	0.73	14/20
SCHEMBL9001806	0.72	14/20
SCHEMBL9001827	0.71	14/20
SCHEMBL9001763	0.69	14/20
SCHEMBL9001820	0.68	14/20
SCHEMBL9001782	0.68	14/20
SCHEMBL9001757	0.66	14/20
SCHEMBL9001842	0.64	14/20
SCHEMBL9001772	0.63	14/20
SCHEMBL9001754	0.60	14/20

Clinical trials — most relevant to SHMT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters.	PHASE2/PHASE3	UNKNOWN
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation	PHASE2	UNKNOWN
Safety and Impact of Dasatinib on Viral Persistence and Inflammation in People With HIV Under Antiretroviral Treatment	PHASE2	COMPLETED
A Placebo-controlled Trial of Folinic Acid in Children With ASD	PHASE2	RECRUITING
Phase 1/ Phase 2 Study to Assess Safety and Efficacy of Orally Administered JBI-802 in Subjects With Myeloproliferative Neoplasms (MPN) and Myelodysplastic/Myeloproliferative Neoplasms (MDS/MPN) With Thrombocytosis	PHASE1/PHASE2	RECRUITING
Study of SGN1 in Patients With Advanced Solid Tumor	PHASE1/PHASE2	RECRUITING
Eltrombopag as a Novel Therapeutic Approach for Low-risk MDS and CMML With TET2 Mutations	PHASE2	SUSPENDED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation	PHASE1	COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas	nan	RECRUITING
Expression of TET1 Gene in Acute Leukaemia	nan	UNKNOWN
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Clinical Trials Using HepatoKeeper Herbal Essentials to Treat Non-alcoholic Fatty Liver Disease and Metabolic Factors	nan	COMPLETED
DNA Methylation and Arsenic-associated Urothelial Carcinoma	nan	UNKNOWN
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SHMT1 binder may also engage these)

Protein	Name	Similarity
Q5RFK5	—	1.000	Q5RFK5 →
P50431	—	1.000	P50431 →
Q9SVM4	—	1.000	Q9SVM4 →
O23254	—	1.000	O23254 →
B0BC69	—	1.000	B0BC69 →
Q3KLR8	—	1.000	Q3KLR8 →
P35623	—	1.000	P35623 →
P50432	—	1.000	P50432 →
Q9PJW0	—	1.000	Q9PJW0 →
P49357	—	0.999	P49357 →
A1BE30	—	0.999	A1BE30 →
Q8KC36	—	0.998	Q8KC36 →
P34898	—	0.998	P34898 →
Q54EW1	—	0.998	Q54EW1 →
A0M3N2	—	0.997	A0M3N2 →
Q54Z26	—	0.997	Q54Z26 →
A7FFW1	—	0.997	A7FFW1 →
Q10104	—	0.997	Q10104 →
O13972	—	0.997	O13972 →
B0B804	—	0.996	B0B804 →
Q94C74	—	0.996	Q94C74 →
Q5LD58	—	0.996	Q5LD58 →
A6L5K3	—	0.996	A6L5K3 →
P07511	—	0.996	P07511 →
Q7MXW0	—	0.996	Q7MXW0 →
B7JYG9	—	0.996	B7JYG9 →
Q5E9P9	—	0.996	Q5E9P9 →
B2K9S8	—	0.995	B2K9S8 →
B1JRX7	—	0.995	B1JRX7 →
Q1CKB8	—	0.995	Q1CKB8 →