Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914491 | 0.93 | KCNA5 (0.49) | KCNA5MMP1MMP9MMP13ADAM17 | |
| SCHEMBL3925872 | 0.89 | KCNA5 (0.43) | KCNA5KCNH2POLB | |
| SCHEMBL3916070 | 0.87 | KCNA5 (0.44) | KCNA5MMP1MMP9MMP13ADAM17 | |
| SCHEMBL3917852 | 0.85 | KCNA5 (0.57) | KCNA5ALDH1A1LMNAKCNH2 | |
| SCHEMBL3925802 | 0.81 | KCNA5 (0.50) | KCNA5ALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL3925563 | 0.80 | KCNA5 (0.44) | KCNA5ALDH1A1LMNAKCNH2 | |
| SCHEMBL3920282 | 0.75 | KCNA5 (0.43) | KCNA5ALDH1A1LMNAKCNH2 | |
| SCHEMBL3916710 | 0.75 | KCNA5 (0.43) | KCNA5KCNH2 | |
| SCHEMBL2887476 | 0.75 | KCNA5 (0.56) | KCNA5KCNH2 | |
| SCHEMBL3925128 | 0.74 | KCNA5 (0.41) | KCNA5MMP1MMP9MMP13KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |