SCHEMBL3915534

SCHEMBL3915534

CCOC(=O)c1ccc(-c2cc(NC(=O)C3CCCCC3)ccc2C)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 5/20 0.68
RAB9A P51151 3/20 0.65
ALDH1A1 P00352 4/20 0.60
POLB P06746 2/20 0.60
HTT P42858 2/20 0.60
NPC1 O15118 2/20 0.57
SMN1; SMN2 Q16637 3/20 0.54
GAA P10253 1/20 0.54
ABL1 P00519 1/20 0.54
LMNA P02545 2/20 0.54
MAPT P10636 2/20 0.54
NPSR1 Q6W5P4 1/20 0.54
TP53 P04637 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C9 P11712 1/20 0.51
HPGD P15428 1/20 0.51
CYP2C19 P33261 1/20 0.51
PTPN1 P18031 1/20 0.50
KMT2A Q03164 1/20 0.50
MAPK1 P28482 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3926783 0.94 RAB9A (0.73) MAPK14RAB9AALDH1A1POLBHTT
SCHEMBL2350255 0.89 RAB9A (0.62) MAPK14RAB9AALDH1A1POLBHTT
SCHEMBL16669620 0.86 RAB9A (0.86) RAB9AALDH1A1POLBHTTNPC1
SCHEMBL2911825 0.85 MAPK14 (0.71) MAPK14ALDH1A1SMN1; SMN2ABL1LMNA
SCHEMBL2342855 0.85 MAPK14 (0.71) MAPK14ALDH1A1SMN1; SMN2ABL1LMNA
SCHEMBL2912814 0.84 MAPK14 (0.71) MAPK14RAB9AALDH1A1HTTNPC1
SCHEMBL2348552 0.83 LDLR (0.57) MAPK14ALDH1A1POLBHTTSMN1; SMN2
SCHEMBL2348359 0.83 RAB9A (0.68) MAPK14RAB9AALDH1A1POLBHTT
SCHEMBL25233963 0.82 RAB9A (0.89) RAB9AALDH1A1POLBHTTNPC1
SCHEMBL2915194 0.82 MAPK14 (0.71) MAPK14RAB9AHTTNPC1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2038253-A1 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C Arrow Therapeutics Limited (GB) 2009-03-25 EP disclosed
WO-2007138242-A1 BIPHENYL DERIVATIVES AND THEIR USE IN TREATING HEPATITIS C ARROW THERAPEUTICS LIMITED (GB) 2007-12-06 WO disclosed